From the exhibition
The Gout
http://data.europeana.eu/agent/148259 · James Gillray, 1799

A grotesquely swollen, scarlet big toe is attacked by a black imp — clawed, fanged, and barbed-tailed — biting and clutching the inflamed joint with savage relish. Gillray rendered the creature in soft-ground etching with hand-applied watercolor, a technique that allowed the supple, almost fleshy modeling of the distended foot alongside the inky menace of the demon. The caption reads simply *The Gout*. Gillray's genius here is medical allegory stripped of allegory's usual dignity: pain is literalized as a monster. This single-image print sits squarely in the British satirical tradition — Hogarth's moral series, Rowlandson's bodily grotesquerie — that taught artists to compress narrative and argument into one charged scene. That compression, the panel that tells everything at once, is the direct ancestor of the comic strip panel and the superhero splash page.
Public domain, restored and presented by comicbooks.com http://creativecommons.org/licenses/by/4.0/